Double Hit Lymphoma Mimicking B Cell Precursor Phenotype Burkitt Lymphoma/Leukemia in an Elderly

Background: The differential diagnosis of Burkitt lymphoma/leukemia (BL) and the double or triple hit lymphomas remains often problematic in terms immunophenotyping association with MYC gene analysis. In past, BL-like B-cell malignancy precursor phenotype (BCP-ALL) was described. Case Report: We report here an 84-year-old male massive ascites without superficial lymphadenopathy. Abdominal paracentesis revealed chylous (non-bloody) consisting mostly abnormal blasts showing CD20-negative BCP phenotype. However, molecular study indicated no MYC/IGH, but probable involvements MYC/IGL BCL6/IGH translocations, which were confirmed by FISH studies. patient diagnosed as lymphoma mimicking BCP-ALL.